LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages.

Omarjee, Ommar; Mathieu, Anne-Laure; Quiniou, Gaëlle; Moreews, Marion; Ainouze, Michelle; Frachette, Cécile; Melki, Isabelle; Dumaine, Cécile; Gerfaud-Valentin, Mathieu; Duquesne, Agnès; Kallinich, Tilmann; Tahir Turanli, Eda; Malcus, Christophe; Viel, Sébastien; Pescarmona, Rémi; Georgin-Lavialle, Sophie; Jamilloux, Yvan; Larbre, Jean-Paul; Sarrabay, Guillaume; Magnotti, Flora; Rice, Gillian I; Bleicher, Francoise; Reboulet, Jonathan; Merabet, Samir; Henry, Thomas; Crow, Yanick J; Faure, Mathias; Walzer, Thierry; Belot, Alexandre

Omarjee, Ommar; Mathieu, Anne-Laure; Quiniou, Gaëlle; Moreews, Marion; Ainouze, Michelle; Frachette, Cécile; Melki, Isabelle; Dumaine, Cécile; Gerfaud-Valentin, Mathieu; Duquesne, Agnès; Kallinich, Tilmann; Tahir Turanli, Eda; Malcus, Christophe; Viel, Sébastien; Pescarmona, Rémi; Georgin-Lavialle, Sophie; Jamilloux, Yvan; Larbre, Jean-Paul; Sarrabay, Guillaume; Magnotti, Flora; Rice, Gillian I; Bleicher, Francoise; Reboulet, Jonathan; Merabet, Samir; Henry, Thomas; Crow, Yanick J; Faure, Mathias; Walzer, Thierry; Belot, Alexandre.

Afiliação

Omarjee O; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Mathieu AL; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Quiniou G; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Moreews M; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Ainouze M; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Frachette C; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Melki I; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Dumaine C; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Gerfaud-Valentin M; Pediatric Nephrology, Rheumatology, Dermatology Department, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
Duquesne A; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Kallinich T; General Pediatrics, Infectious Disease and Internal Medicine Department, Hôpital Robert Debre, Assistance Publique-Hôpitaux de Paris, Paris, France.
Tahir Turanli E; Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes-Sorbonne Paris Cité University, Institut Imagine, Hôpital Necker, Paris, France.
Malcus C; General Pediatrics, Infectious Disease and Internal Medicine Department, Hôpital Robert Debre, Assistance Publique-Hôpitaux de Paris, Paris, France.
Viel S; Internal Medicine, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France.
Pescarmona R; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Georgin-Lavialle S; Pediatric Nephrology, Rheumatology, Dermatology Department, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Bron, France.
Jamilloux Y; Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité University Medicine Berlin, German Rheumatism Research Center, Leibniz Association, Berlin Institute of Health, Berlin, Germany.
Larbre JP; Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Turkey.
Sarrabay G; Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Magnotti F; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Rice GI; Immunology Department, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Bleicher F; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Reboulet J; Immunology Department, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Merabet S; National Referee Centre for Rheumatic and Autoimmune Diseases in Children, RAISE, Paris and Lyon, France.
Henry T; Immunology Department, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
Crow YJ; Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Sorbonne Université, Service de Médecine Interne, Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses d'Origine Inflammatoire, Paris, France.
Faure M; Assistance Publique-Hôpitaux de Paris, Hôpital Trousseau, Université Pierre-et-Marie-Curie-Paris 6, Institut National de la Santé et de la Recherche Médicale UMRS 933, Paris, France.
Walzer T; Centre International de Recherche en Infectiologie/International Center for Infectiology Research, Institut National de la Santé et de la Recherche Médicale, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, Centre National de la Recherche Scientifique, UMR5308, Lyon, France.
Belot A; Internal Medicine, Croix Rousse Hospital, Hospices Civils de Lyon, Lyon, France.

J Exp Med ; 218(3)2021 03 01.

Article em En | MEDLINE | ID: mdl-33606008

Assuntos

Artrite Juvenil/metabolismo; Artrite Juvenil/patologia; Autofagia; Peptídeos e Proteínas de Sinalização Intracelular/deficiência; Macrófagos/metabolismo; Adenilato Quinase/metabolismo; Adolescente; Sequência de Aminoácidos; Apoptose/efeitos dos fármacos; Artrite Juvenil/genética; Autofagia/efeitos dos fármacos; Autofagia/genética; Proteínas Relacionadas à Autofagia/metabolismo; Bactérias/metabolismo; Diferenciação Celular/efeitos dos fármacos; Criança; Exoma/genética; Feminino; Homozigoto; Humanos; Inflamassomos/metabolismo; Inflamação/complicações; Inflamação/patologia; Interferons/metabolismo; Peptídeos e Proteínas de Sinalização Intracelular/química; Peptídeos e Proteínas de Sinalização Intracelular/genética; Gotículas Lipídicas/efeitos dos fármacos; Gotículas Lipídicas/metabolismo; Mutação com Perda de Função/genética; Lisossomos/efeitos dos fármacos; Lisossomos/metabolismo; Fator Estimulador de Colônias de Macrófagos/farmacologia; Macrófagos/efeitos dos fármacos; Masculino; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Monócitos/efeitos dos fármacos; Monócitos/patologia; NF-kappa B/metabolismo; Linhagem; Proteômica; Receptores de Quinase C Ativada/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Adulto Jovem

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Juvenil / Autofagia / Peptídeos e Proteínas de Sinalização Intracelular / Macrófagos Idioma: En Revista: J Exp Med Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França

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