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Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.
Matthew, Susan; Chen, Qi-Yin; Ratnayake, Ranjala; Fermaintt, Charles S; Lucena-Agell, Daniel; Bonato, Francesca; Prota, Andrea E; Lim, Seok Ting; Wang, Xiaomeng; Díaz, J Fernando; Risinger, April L; Paul, Valerie J; Oliva, Maria Ángela; Luesch, Hendrik.
Afiliação
  • Matthew S; Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610.
  • Chen QY; Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610.
  • Ratnayake R; Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610.
  • Fermaintt CS; Department of Medicinal Chemistry, University of Florida, Gainesville, FL 32610.
  • Lucena-Agell D; Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610.
  • Bonato F; Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
  • Prota AE; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
  • Lim ST; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
  • Wang X; Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.
  • Díaz JF; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921 Singapore.
  • Risinger AL; Lee Kong Chian School of Medicine, Nanyang Technological University, 636921 Singapore.
  • Paul VJ; Centro de Investigaciones Biológicas Margarita Salas, Consejo Superior de Investigaciones Científicas, 28040 Madrid, Spain.
  • Oliva MÁ; Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
  • Luesch H; Smithsonian Marine Station, Fort Pierce, FL 34949.
Proc Natl Acad Sci U S A ; 118(9)2021 03 02.
Article em En | MEDLINE | ID: mdl-33619102
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tubulina (Proteína) / Produtos Biológicos / Depsipeptídeos / Moduladores de Tubulina / Microtúbulos / Antineoplásicos Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Tubulina (Proteína) / Produtos Biológicos / Depsipeptídeos / Moduladores de Tubulina / Microtúbulos / Antineoplásicos Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article