Inhibition of radiation-induced transformation in vitro by bacterial endotoxins.
Carcinogenesis
; 9(5): 725-9, 1988 May.
Article
em En
| MEDLINE
| ID: mdl-3365832
ABSTRACT
Bacterial endotoxins (lipopolysaccharides) were found to suppress X-ray-induced malignant transformation of C3H/10T1/2 cells. Endotoxins were effective if present either throughout the 6-week transformation assay period, or for the final 4-week phase, but not when present only for the initial 2-week phase. Neither growth nor survival of C3H/10T1/2 cells, or a radiation-transformed cell line derived from them, were affected by endotoxins. Also, the endotoxins did not affect the formation of foci by the radiation transformed cells when these cells were co-cultured with untransformed cells. These results suggest that endotoxins exert their effect directly upon the transformation process itself, perhaps at a 'late' step in the conversion of an untransformed to a transformed cell.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Endotoxinas
Limite:
Animals
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
1988
Tipo de documento:
Article