Susceptibility and resistance in leprosy: Studies in the mouse model.
Immunol Rev
; 301(1): 157-174, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-33660297
ABSTRACT
Leprosy is a chronic granulomatous infectious disease caused by the pathogen, Mycobacterium leprae, and the more recently discovered, M. lepromatosis. Described in 1873, M. leprae was among the first microorganisms to be proposed as a cause of a human infectious disease. As an obligate intracellular bacterium, it has still not thus far been reproducibly cultivated in axenic medium or cell cultures. Shepard's mouse footpad assay, therefore, was truly a breakthrough in leprosy research. The generation of immunosuppressed and genetically engineered mice, along with advances in molecular and cellular techniques, has since offered more tools for the study of the M. leprae-induced granuloma. While far from perfect, these new mouse models have provided insights into the immunoregulatory mechanisms responsible for the spectrum of this complex disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hanseníase
Limite:
Animals
Idioma:
En
Revista:
Immunol Rev
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos