Efficient biosynthesis of (2S, 3R)-4-methylsulfonylphenylserine by artificial self-assembly of enzyme complex combined with an intensified acetaldehyde elimination system.

Xu, Lian; Wang, Li-Chao; Su, Bing-Mei; Xu, Xin-Qi; Lin, Juan

Xu, Lian; Wang, Li-Chao; Su, Bing-Mei; Xu, Xin-Qi; Lin, Juan.

Afiliação

Xu L; College of Chemical Engineering, Fuzhou University, Fuzhou 350116, China.
Wang LC; College of Chemical Engineering, Fuzhou University, Fuzhou 350116, China.
Su BM; College of Chemical Engineering, Fuzhou University, Fuzhou 350116, China.
Xu XQ; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, China.
Lin J; College of Chemical Engineering, Fuzhou University, Fuzhou 350116, China; College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, China. Electronic address: ljuan@fzu.edu.cn.

Bioorg Chem ; 110: 104766, 2021 05.

Article em En | MEDLINE | ID: mdl-33662895

Assuntos

Acetaldeído/química; Desenho de Fármacos; Catálise; Enzimas/genética; Enzimas/metabolismo; Escherichia coli/enzimologia; Escherichia coli/genética; Engenharia Genética; Concentração de Íons de Hidrogênio; Temperatura

Palavras-chave

(2S, 3R)-4-methylsulfonylphenylserine; Acetaldehyde elimination system; Multi-enzyme cascade; SpyTag/SpyCatcher conjugation; l-threonine transaldolase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Acetaldeído Idioma: En Revista: Bioorg Chem Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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