Carbon-11 carboxylation of terminal alkynes with [11 C]CO2.
J Labelled Comp Radiopharm
; 64(6): 237-242, 2021 05 30.
Article
em En
| MEDLINE
| ID: mdl-33665888
ABSTRACT
A copper-catalysed radiosynthesis of carbon-11 radiolabelled carboxylic acids was developed by reacting terminal alkynes and cyclotron-produced carbon-11 carbon dioxide ([11 C]CO2 ) in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). A small library of 11 C-labelled propiolic acid derivatives were obtained with a total synthesis time of 15 min from end of bombardment (EOB) with a (non-isolated) radiochemical yield ranging from 7% to 28%.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dióxido de Carbono
Idioma:
En
Revista:
J Labelled Comp Radiopharm
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Guadalupe