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Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
O' Donovan, Daniel H; Gregson, Clare; Packer, Martin J; Greenwood, Ryan; Pike, Kurt G; Kawatkar, Sameer; Bloecher, Andrew; Robinson, James; Read, Jon; Code, Erin; Hsu, Jessie Hao-Ru; Shen, Minhui; Woods, Haley; Barton, Peter; Fillery, Shaun; Williamson, Beth; Rawlins, Philip B; Bagal, Sharan K.
Afiliação
  • O' Donovan DH; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom. Electronic address: daniel.odonovan@astrazeneca.com.
  • Gregson C; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Packer MJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Greenwood R; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Pike KG; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Kawatkar S; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Bloecher A; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Robinson J; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Read J; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Code E; Discovery Sciences R&D, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Hsu JH; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Shen M; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Woods H; Oncology R&D, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, United States.
  • Barton P; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Fillery S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Williamson B; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Rawlins PB; Discovery Sciences R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
  • Bagal SK; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.
Bioorg Med Chem Lett ; 39: 127904, 2021 05 01.
Article em En | MEDLINE | ID: mdl-33684441
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Termodinâmica / Desenho de Fármacos / Inibidores Enzimáticos / Complexo Repressor Polycomb 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Termodinâmica / Desenho de Fármacos / Inibidores Enzimáticos / Complexo Repressor Polycomb 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article