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Single dose testosterone administration enhances novelty responsiveness and short-term habituation in healthy males.
Fang, Huihua; Li, Xiaoyun; Zhang, Wenyun; Fan, Bi; Wu, Yin; Peng, Weiwei.
Afiliação
  • Fang H; School of Psychology, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen, China; Department of Psychology, University of Mannheim, Mannheim, Germany.
  • Li X; School of Psychology, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen, China.
  • Zhang W; School of Psychology, Shenzhen University, Shenzhen, China.
  • Fan B; School of Management, Shenzhen University, Shenzhen, China.
  • Wu Y; School of Psychology, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen, China; School of Psychology, Shanghai University of Sport, Shanghai, China.
  • Peng W; School of Psychology, Shenzhen University, Shenzhen, China; Shenzhen Key Laboratory of Affective and Social Cognitive Science, Shenzhen University, Shenzhen, China. Electronic address: ww.peng0923@gmail.com.
Horm Behav ; 131: 104963, 2021 05.
Article em En | MEDLINE | ID: mdl-33711638
ABSTRACT
The role of testosterone in sensory perception suggests that testosterone likely regulates adaptive responses to sensory changes, including habituation to repeated events and responsiveness to novel events. To test this hypothesis, we investigated how testosterone modulates brain responses to rapid changes in sensory inputs. Using a double-blind, placebo-controlled, within-participant design, each participant received a single dose of either testosterone or placebo, and then completed a passive auditory oddball task in which infrequent deviant tones were embedded in a series of frequent standard tones. Analysis of novelty-evoked potentials revealed smaller Mismatch Negativity (MMN) responses, but larger P3a responses in the testosterone session than in the placebo session. This suggests testosterone attenuates MMN responses that are associated with pre-attentive novelty detection and enhances P3a responses that are associated with involuntary attentional orientation toward novelty. Along with the repetition of standard tones, P2 responses on the auditory evoked potentials became significantly attenuated in the testosterone session, but not in the placebo session. This suggests testosterone enhances short-term habituation of P2 responses to recurring sensory events, which has been associated with bottom-up attention allocation. Mediation analysis further revealed that the role of testosterone in promoting attentional orientation toward novelty could be explained by the influence it exerts on short-term habituation and pre-attentive novelty detection. Overall, testosterone facilitated involuntary attention switching-withdrawal of attention from repeated sensory events and orientation toward novel sensory events-at the cost of attenuated pre-attentive novelty detection. This finding provides insight into the interplay between endocrinology and involuntary attentional processes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Habituação Psicofisiológica Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: Horm Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testosterona / Habituação Psicofisiológica Tipo de estudo: Clinical_trials Limite: Humans / Male Idioma: En Revista: Horm Behav Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha