Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-<i>trans</i> Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation.

Phillips, Brett E; Garciafigueroa, Yesica; Engman, Carl; Liu, Wen; Wang, Yiwei; Lakomy, Robert J; Meng, Wilson S; Trucco, Massimo; Giannoukakis, Nick

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation.

Phillips, Brett E; Garciafigueroa, Yesica; Engman, Carl; Liu, Wen; Wang, Yiwei; Lakomy, Robert J; Meng, Wilson S; Trucco, Massimo; Giannoukakis, Nick.

Afiliação

Phillips BE; Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.
Garciafigueroa Y; Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.
Engman C; Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.
Liu W; Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.
Wang Y; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States.
Lakomy RJ; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States.
Meng WS; Institute of Cellular Therapeutics, Allegheny Health Network, Pittsburgh, PA, United States.
Trucco M; Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA, United States.
Giannoukakis N; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

Front Immunol ; 12: 586220, 2021.

Article em En | MEDLINE | ID: mdl-33763059

Assuntos

Autoantígenos/imunologia; Autoimunidade/efeitos dos fármacos; Diabetes Mellitus Tipo 1/imunologia; Diabetes Mellitus Tipo 1/metabolismo; Fator de Crescimento Transformador beta1/farmacologia; Tretinoína/farmacologia; Animais; Células Dendríticas; Diabetes Mellitus Experimental; Diabetes Mellitus Tipo 1/diagnóstico; Diabetes Mellitus Tipo 1/tratamento farmacológico; Composição de Medicamentos; Feminino; Insulina/metabolismo; Contagem de Linfócitos; Camundongos; Camundongos Endogâmicos NOD; Pâncreas/metabolismo; Pâncreas/patologia; Índice de Gravidade de Doença; Linfócitos T Reguladores/efeitos dos fármacos; Linfócitos T Reguladores/imunologia; Linfócitos T Reguladores/metabolismo; Fator de Crescimento Transformador beta1/química; Tretinoína/química

Palavras-chave

autoimmunity; immunoregulation; microparticles; tolerance; type 1 diabetes; vaccine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autoantígenos / Tretinoína / Autoimunidade / Diabetes Mellitus Tipo 1 / Fator de Crescimento Transformador beta1 Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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