An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability.

Nagy, Zsuzsanna; Seneviratne, Janith A; Kanikevich, Maxwell; Chang, William; Mayoh, Chelsea; Venkat, Pooja; Du, Yanhua; Jiang, Cizhong; Salib, Alice; Koach, Jessica; Carter, Daniel R; Mittra, Rituparna; Liu, Tao; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M

Nagy, Zsuzsanna; Seneviratne, Janith A; Kanikevich, Maxwell; Chang, William; Mayoh, Chelsea; Venkat, Pooja; Du, Yanhua; Jiang, Cizhong; Salib, Alice; Koach, Jessica; Carter, Daniel R; Mittra, Rituparna; Liu, Tao; Parker, Michael W; Cheung, Belamy B; Marshall, Glenn M.

Afiliação

Nagy Z; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Seneviratne JA; School of Women's and Children's Health, UNSW Sydney, Randwick, NSW, Australia.
Kanikevich M; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Chang W; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Mayoh C; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Venkat P; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Du Y; School of Women's and Children's Health, UNSW Sydney, Randwick, NSW, Australia.
Jiang C; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Salib A; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Koach J; School of Life Sciences and Technology, Tongji University, Shanghai, China.
Carter DR; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Mittra R; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Liu T; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.
Parker MW; School of Women's and Children's Health, UNSW Sydney, Randwick, NSW, Australia.
Cheung BB; School of Biomedical Engineering, University of Technology, Sydney, NSW, Australia.
Marshall GM; Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW, Sydney, NSW, Australia.

Nat Commun ; 12(1): 1881, 2021 03 25.

Article em En | MEDLINE | ID: mdl-33767157

Assuntos

Carcinogênese/patologia; Proteína Proto-Oncogênica N-Myc/metabolismo; Neuroblastoma/patologia; Proteínas Nucleares/metabolismo; Proteínas de Ligação a RNA/metabolismo; Fatores de Transcrição/metabolismo; Proteases Específicas de Ubiquitina/metabolismo; Animais; Carcinogênese/genética; Linhagem Celular Tumoral; Sobrevivência Celular/genética; Cromossomos Humanos Par 17/genética; Variações do Número de Cópias de DNA/genética; Células HEK293; Humanos; Camundongos; Proteína Proto-Oncogênica N-Myc/genética; Neuroblastoma/genética; Proteínas Nucleares/genética; Prognóstico; Interferência de RNA; RNA Interferente Pequeno/genética; Proteínas de Ligação a RNA/genética; Fatores de Transcrição/genética; Transcrição Gênica/genética; Ativação Transcricional/genética; Proteases Específicas de Ubiquitina/genética; Ubiquitinação/fisiologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas Nucleares / Proteínas de Ligação a RNA / Carcinogênese / Proteases Específicas de Ubiquitina / Proteína Proto-Oncogênica N-Myc / Neuroblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Austrália

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