Drug-related adverse effects of antivascular endothelial growth factor agents.
Curr Opin Ophthalmol
; 32(3): 191-197, 2021 May 01.
Article
em En
| MEDLINE
| ID: mdl-33770015
ABSTRACT
PURPOSE OF REVIEW Antivascular endothelial growth factor (VEGF) agents have provided historic therapeutic breakthroughs in the treatment of retinal disease. New anti-VEGF agents are emerging for the treatment of retinal vascular diseases. Both systemic and ocular adverse effect need to be understood in managing patients. This review aims to highlight the adverse effects seen with routine use of bevacizumab, ranibizumab and aflibercept, as well as with new medications such as brolucizumab and abicipar. RECENT FINDINGS:
We review the recent findings of intraocular inflammation (IOI) of brolucizumab and abicipar in the context of the efficacy and safety reported with the routine anti-VEGF agents. Specifically, brolucizumab has been reported to cause occlusive retinal vasculitis in the setting of IOI, which has not been seen in other anti-VEGF medications. In addition, abicipar appears to cause IOI at a higher rate of patients than other anti-VEGF agents have previously.SUMMARY:
Newer anti-VEGF agents pose a significant risk of adverse events not seen with routine anti-VEGF agents.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Angiogênese
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Vasculite Retiniana
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Fator A de Crescimento do Endotélio Vascular
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos