Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta-analysis.
Oral Dis
; 28(4): 1068-1084, 2022 May.
Article
em En
| MEDLINE
| ID: mdl-33774891
ABSTRACT
OBJECTIVES:
Oral mucositis (OM) is an acute toxicity related to cancer treatment. This systematic review aimed to identify potential risk factors associated with the development of OM in pediatric cancer patients.METHODS:
A search was performed in four electronic databases to identify studies that analyzed risk factors for OM in pediatric cancer patients.RESULTS:
Nineteen articles were included. The incidence of OM ranged from 20% to 80.4%. Chemotherapeutic agents were potential risk factors for OM in eight (42%) studies. Hematological, hepatic, and renal parameters were also considered in eight (42%) studies, while specific individual factors were reported in five (26.3%) studies. Baseline disease, oral microbiota, genetic profile, and biomarkers were reported in four (21.5%) studies each. Meta-analysis showed that groups submitted to high-risk chemotherapy for OM had a 2.79-fold increased risk of OM.CONCLUSIONS:
Identifying risk factors for OM is essential in order to allow individualized and early prevention treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estomatite
/
Neoplasias
/
Antineoplásicos
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limite:
Child
/
Humans
Idioma:
En
Revista:
Oral Dis
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Brasil