Plasma homovanillic acid as a predictor of response to neuroleptics.
Arch Gen Psychiatry
; 45(6): 564-7, 1988 Jun.
Article
em En
| MEDLINE
| ID: mdl-3377643
ABSTRACT
Fourteen schizophrenic subjects were evaluated for degree of psychosis before and after treatment with the antipsychotic drug haloperidol and for plasma homovanillic acid concentration after four and 28 days of treatment. A significant correlation was found between an increase in homovanillic acid concentration on day 4 or a decrease from day 4 to day 28 and the degree of improvement after four weeks of treatment. Thus, those patients who had the greatest change in plasma homovanillic acid in response to neuroleptic blockade showed the greatest improvement. These and other observations have led us to propose that the central dopaminergic system, through adaptive changes in activity, serves as a physiologic buffer system protecting against destabilization of mental function from diverse biologic or psychologic insults.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Haloperidol
/
Ácido Homovanílico
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Gen Psychiatry
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Espanha