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Identification of harmine and ß-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies.
Tarpley, Michael; Oladapo, Helen O; Strepay, Dillon; Caligan, Thomas B; Chdid, Lhoucine; Shehata, Hassan; Roques, Jose R; Thomas, Rhashad; Laudeman, Christopher P; Onyenwoke, Rob U; Darr, David B; Williams, Kevin P.
Afiliação
  • Tarpley M; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
  • Oladapo HO; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; INBS PhD Program, North Carolina Central University, Durham, NC 27707, USA.
  • Strepay D; Department of Biological and Biomedical Sciences, North Carolina Central University, Durham, NC 27707, USA.
  • Caligan TB; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
  • Chdid L; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
  • Shehata H; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; INBS PhD Program, North Carolina Central University, Durham, NC 27707, USA.
  • Roques JR; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA.
  • Thomas R; Department of Pharmaceutical Sciences; North Carolina Central University, Durham, NC 27707, USA.
  • Laudeman CP; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA.
  • Onyenwoke RU; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; Department of Pharmaceutical Sciences; North Carolina Central University, Durham, NC 27707, USA.
  • Darr DB; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27514, USA.
  • Williams KP; Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA; Department of Pharmaceutical Sciences; North Carolina Central University, Durham, NC 27707, USA. Electronic address: kpwilliams@nccu.edu.
Eur J Pharm Sci ; 162: 105821, 2021 Jul 01.
Article em En | MEDLINE | ID: mdl-33781856
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Inibidores da Monoaminoxidase / Neoplasias / Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Serina-Treonina Quinases / Inibidores da Monoaminoxidase / Neoplasias / Antineoplásicos Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos