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Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi.
Pramisandi, Amila; Kurnia, Kesi; Chrisnayanti, Evita; Bernawati, Putri; Dobashi, Kazuyuki; Mori, Mihoko; Mahsunah, Anis Herliyati; Nonaka, Kenichi; Matsumoto, Atsuko; Hidayati, Dyah Noor; Dewi, Diana; Prabandari, Erwahyuni Endang; Amalia, Eri; Rahmawati, Yulia; Nurkanto, Arif; Inaoka, Daniel Ken; Waluyo, Danang; Kita, Kiyoshi; Nozaki, Tomoyoshi; Omura, Satoshi; Shiomi, Kazuro.
Afiliação
  • Pramisandi A; Graduate School of Infection Control Sciences, Kitasato University.
  • Kurnia K; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Chrisnayanti E; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Bernawati P; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Dobashi K; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Mori M; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Mahsunah AH; Graduate School of Infection Control Sciences, Kitasato University.
  • Nonaka K; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Matsumoto A; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Kristiningrum; Graduate School of Infection Control Sciences, Kitasato University.
  • Hidayati DN; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Dewi D; Graduate School of Infection Control Sciences, Kitasato University.
  • Prabandari EE; Department of Drug Discovery Sciences, Kitasato Institute for Life Sciences.
  • Amalia E; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Rahmawati Y; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Nurkanto A; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Inaoka DK; Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
  • Waluyo D; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Kita K; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
  • Omura S; Research Center for Biology, Indonesia Institute of Sciences (LIPI).
  • Shiomi K; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo.
J Gen Appl Microbiol ; 67(3): 114-117, 2021 Jul 31.
Article em En | MEDLINE | ID: mdl-33814517
ABSTRACT
Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 3.4 µM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC50 value of 47.6 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Álcoois Benzílicos / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Fungos / Ácido Homogentísico Idioma: En Revista: J Gen Appl Microbiol Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plasmodium falciparum / Álcoois Benzílicos / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Fungos / Ácido Homogentísico Idioma: En Revista: J Gen Appl Microbiol Ano de publicação: 2021 Tipo de documento: Article