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Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.
Konteatis, Zenon; Travins, Jeremy; Gross, Stefan; Marjon, Katya; Barnett, Amelia; Mandley, Everton; Nicolay, Brandon; Nagaraja, Raj; Chen, Yue; Sun, Yabo; Liu, Zhixiao; Yu, Jie; Ye, Zhixiong; Jiang, Fan; Wei, Wentao; Fang, Cheng; Gao, Yi; Kalev, Peter; Hyer, Marc L; DeLaBarre, Byron; Jin, Lei; Padyana, Anil K; Dang, Lenny; Murtie, Joshua; Biller, Scott A; Sui, Zhihua; Marks, Kevin M.
Afiliação
  • Konteatis Z; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Travins J; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Gross S; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Marjon K; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Barnett A; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Mandley E; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Nicolay B; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Nagaraja R; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Chen Y; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Sun Y; Viva Biotech, Shanghai 201203, China.
  • Liu Z; Viva Biotech, Shanghai 201203, China.
  • Yu J; Viva Biotech, Shanghai 201203, China.
  • Ye Z; Viva Biotech, Shanghai 201203, China.
  • Jiang F; Viva Biotech, Shanghai 201203, China.
  • Wei W; Viva Biotech, Shanghai 201203, China.
  • Fang C; ChemPartner, Shanghai 201203, China.
  • Gao Y; ChemPartner, Shanghai 201203, China.
  • Kalev P; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Hyer ML; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • DeLaBarre B; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Jin L; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Padyana AK; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Dang L; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Murtie J; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Biller SA; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Sui Z; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
  • Marks KM; Agios Pharmaceuticals, Inc., 88 Sidney Street, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 64(8): 4430-4449, 2021 04 22.
Article em En | MEDLINE | ID: mdl-33829783
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purina-Núcleosídeo Fosforilase / Inibidores Enzimáticos / Metionina Adenosiltransferase Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purina-Núcleosídeo Fosforilase / Inibidores Enzimáticos / Metionina Adenosiltransferase Limite: Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos