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The Application of Mass Spectrometry in Drug Metabolism and Pharmacokinetics.
Lee, Ji-Yoon; Kim, Sang Kyum; Lee, Kiho; Oh, Soo Jin.
Afiliação
  • Lee JY; Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea.
  • Kim SK; College of Pharmacy, Chungnam National University, Daejeon, South Korea.
  • Lee K; College of Pharmacy, Korea University, Sejong, South Korea.
  • Oh SJ; Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea. diatree@amc.seoul.kr.
Adv Exp Med Biol ; 1310: 533-550, 2021.
Article em En | MEDLINE | ID: mdl-33834449
Drug metabolism and pharmacokinetics (DMPK) are fundamental in drug discovery. New chemical entities (NCEs) are typically evaluated with various in vitro and in vivo assays, which are time-consuming and labor intensive. These experiments are essential in identifying potential new drugs. Recently, mass spectrometry (MS) has played a key role in examining the drug-like properties of NCEs. Quantitative and qualitative mass spectrometry approaches are routinely utilized to obtain high-quality data in an efficient, timely, and cost-effective manner. Especially, liquid chromatography (LC) coupled with MS technology has been refined for metabolite identification (Met ID), which is critical for lead optimization. These qualitative and quantitative MS approaches and their specific utility in DMPK characterization will be described in this chapter.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Descoberta de Drogas Tipo de estudo: Qualitative_research Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Descoberta de Drogas Tipo de estudo: Qualitative_research Idioma: En Revista: Adv Exp Med Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Coréia do Sul