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New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26.
Pan, Guojun; Li, Yanling; Che, Xinyu; Tian, Dan; Han, Wenjie; Wang, Zimin; Zhao, Yanfen; Ren, Shuang; Xu, Yiru; Hao, Gangping; Guo, Mengfei; Xiao, Na; Kong, Fandong.
Afiliação
  • Pan G; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Li Y; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Che X; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.
  • Tian D; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.
  • Han W; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Wang Z; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Zhao Y; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Ren S; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Xu Y; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Hao G; College of Life Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Tai'an, China.
  • Guo M; Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineer
  • Xiao N; State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, China.
  • Kong F; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Front Microbiol ; 12: 668938, 2021.
Article em En | MEDLINE | ID: mdl-33841388
ABSTRACT
Two new thio-compounds named aspergerthinol A and B (1 and 2) and two new monoterpenes named aspergerthinacids A and B (3 and 4) were isolated from the fungus Aspergillus sp. CYH26 from the rhizosphere soil of Cynanchum bungei Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds 1 and 2 represented a new family of sulfur containing natural products with a 3-methyl-4H-cyclopenta[b]thiophen-4-one skeleton. Compounds 1-4 showed inhibitory activities against nitric oxide (NO) with IC50 values of 38.0, 19.8, 46.3, and 56.6 µM, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Microbiol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China