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Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.
Voll, Andreas M; Meyners, Christian; Taubert, Martha C; Bajaj, Thomas; Heymann, Tim; Merz, Stephanie; Charalampidou, Anna; Kolos, Jürgen; Purder, Patrick L; Geiger, Thomas M; Wessig, Pablo; Gassen, Nils C; Bracher, Andreas; Hausch, Felix.
Afiliação
  • Voll AM; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Meyners C; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Taubert MC; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Bajaj T; Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, Venusberg Campus 1, 53127, Bonn, Germany.
  • Heymann T; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Merz S; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Charalampidou A; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Kolos J; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Purder PL; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Geiger TM; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
  • Wessig P; Universität Potsdam, Institut für Chemie, Karl-Liebknecht-Strasse 24-25, 14476, Potsdam, Germany.
  • Gassen NC; Research Group Neurohomeostasis, Department of Psychiatry and Psychotherapy, University of Bonn, Venusberg Campus 1, 53127, Bonn, Germany.
  • Bracher A; Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany.
  • Hausch F; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Strasse 4, 64287, Darmstadt, Germany.
Angew Chem Int Ed Engl ; 60(24): 13257-13263, 2021 06 07.
Article em En | MEDLINE | ID: mdl-33843131
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Tacrolimo / Ligantes Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ligação a Tacrolimo / Ligantes Limite: Humans Idioma: En Revista: Angew Chem Int Ed Engl Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha