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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety.
Sainas, Stefano; Giorgis, Marta; Circosta, Paola; Gaidano, Valentina; Bonanni, Davide; Pippione, Agnese C; Bagnati, Renzo; Passoni, Alice; Qiu, Yaqi; Cojocaru, Carina Florina; Canepa, Barbara; Bona, Alessandro; Rolando, Barbara; Mishina, Mariia; Ramondetti, Cristina; Buccinnà, Barbara; Piccinini, Marco; Houshmand, Mohammad; Cignetti, Alessandro; Giraudo, Enrico; Al-Karadaghi, Salam; Boschi, Donatella; Saglio, Giuseppe; Lolli, Marco L.
Afiliação
  • Sainas S; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Giorgis M; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Circosta P; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
  • Gaidano V; Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy.
  • Bonanni D; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
  • Pippione AC; Division of Hematology, AO SS Antonio e Biagio e Cesare Arrigo, Via Venezia 16, Alessandria 15121, Italy.
  • Bagnati R; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Passoni A; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Qiu Y; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
  • Cojocaru CF; Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, Milano 20156, Italy.
  • Canepa B; Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy.
  • Bona A; Higher Education Mega Center, Institutes for Life Sciences, South China University of Technology, Guangzhou 510641, China.
  • Rolando B; Laboratory of Tumor Microenvironment, Candiolo Cancer Institute, FPO, IRCCS, Candiolo, Strada Provinciale, 142-KM 3.95, Candiolo, Turin 10060, Italy.
  • Mishina M; Gem Forlab srl, Via Ribes, 5, Colleretto Giacosa, Turin 10010, Italy.
  • Ramondetti C; Gem Chimica srl, Via Maestri del Lavoro, 25, Busca, Cuneo 12022, Italy.
  • Buccinnà B; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Piccinini M; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Houshmand M; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Cignetti A; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Giraudo E; Department of Oncology, University of Turin, Via Michelangelo 27/B, Turin 10125, Italy.
  • Al-Karadaghi S; Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, Orbassano, Turin 10043, Italy.
  • Boschi D; Molecular Biotechnology Center, University of Turin, Via Nizza 52, Turin 10126, Italy.
  • Saglio G; Division of Hematology and Cell Therapy, AO Ordine Mauriziano, Largo Filippo Turati, 62, Turin 10128, Italy.
  • Lolli ML; Department of Drug Science and Technology, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
J Med Chem ; 64(9): 5404-5428, 2021 05 13.
Article em En | MEDLINE | ID: mdl-33844533
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Compostos de Bifenilo / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirazóis / Piridinas / Compostos de Bifenilo / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos Limite: Animals / Female / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália