Infantile leukemia-What factors determine its distinct biological nature? Clinicopathological study of 78 cases.
Int J Lab Hematol
; 43(5): 1117-1122, 2021 Oct.
Article
em En
| MEDLINE
| ID: mdl-33847065
ABSTRACT
INTRODUCTION:
Infantile leukemia encompasses a heterogeneous group which needs stratifying for treatment selection.METHODS:
We collected 78 cases of infantile leukemia and retrospectively analyzed their clinicopathological data.RESULTS:
Infantile leukemia featured a ratio of acute myeloid leukemia (AML) to B-lymphoblastic leukemia (B-ALL) of 12, with a better survival for AML than B-ALL (median survival 36 vs 24 months). When stratified by age, "early" infantile B-ALL (2-6 months) showed a high rate of KMT2A rearrangement (100%), similar to the rate seen in congenital B-ALL (1 month) (100%) and higher than seen in "late" infantile B-ALL (≥7 months) (68%). The three categories of infantile B-ALL exhibited an age-dependent increase in survival (median survival 8.5, 24, and >24 months, respectively). The age-dependent survival benefit remained after excluding the cases negative for KMT2A rearrangement. Conversely, infantile AML lacked an age-dependent pattern of survival.CONCLUSION:
The clinical outcome of infantile leukemia depends on the type of leukemia. Given the age-dependent survival, infantile B-ALL can be divided into three subcategories.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Int J Lab Hematol
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos