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Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment.
Li, Peng; Mu, Junya; Ma, Xueying; Ding, Dun; Ma, Shaohui; Zhang, Huawen; Liu, Jixin; Zhang, Ming.
Afiliação
  • Li P; Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, China.
  • Mu J; Department of Medical Imaging, Hospital of Shaanxi Nuclear Geology, Xianyang, China.
  • Ma X; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
  • Ding D; Department of Medical Imaging, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
  • Ma S; Department of Medical Imaging, The Second Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, China.
  • Zhang H; Department of Medical Imaging, First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, China.
  • Liu J; Department of Medical Imaging, Hospital of Shaanxi Nuclear Geology, Xianyang, China.
  • Zhang M; Center for Brain Imaging, School of Life Science and Technology, Xidian University, Xi'an, China.
J Cereb Blood Flow Metab ; 41(10): 2593-2606, 2021 10.
Article em En | MEDLINE | ID: mdl-33853410
ABSTRACT
We aimed to investigate the neurovascular coupling (NVC) dysfunction in end-stage renal disease (ESRD) patients related with cognitive impairment. Twenty-five ESRD patients and 22 healthy controls were enrolled. To assess the NVC dysfunctional pattern, resting-state functional MRI and arterial spin labeling were explored to estimate the coupling of spontaneous neuronal activity and cerebral blood perfusion based on amplitude of low-frequency fluctuation (ALFF)-cerebral blood flow (CBF), fractional ALFF (fALFF)-CBF, regional homogeneity (ReHo)-CBF, and degree centrality (DC)-CBF correlation coefficients. Multivariate partial least-squares correlation and mediation analyses were used to evaluate the relationship among NVC dysfunctional pattern, cognitive impairment and clinical characteristics. The NVC dysfunctional patterns in ESRD patients were significantly decreased in 34 brain regions compared with healthy controls. The decreased fALFF-CBF coefficients in the cingulate gyrus (CG) were associated positively with lower kinetic transfer/volume urea (Kt/V) and lower short-term memory scores, and were negatively associated with higher serum urea. The relationship between Kt/V and memory deficits of ESRD patients was partially mediated by the fALFF-CBF alteration of the CG. These findings reveal the NVC dysfunction may be a potential neural mechanism for cognitive impairment in ESRD. The regional NVC dysfunction may mediate the impact of dialysis adequacy on memory function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva / Acoplamento Neurovascular / Falência Renal Crônica Limite: Adult / Female / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Cognitiva / Acoplamento Neurovascular / Falência Renal Crônica Limite: Adult / Female / Humans / Male Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China