Remapping and realignment in the human hippocampal formation predict context-dependent spatial behavior.
Nat Neurosci
; 24(6): 863-872, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-33859438
ABSTRACT
To guide spatial behavior, the brain must retrieve memories that are appropriately associated with different navigational contexts. Contextual memory might be mediated by cell ensembles in the hippocampal formation that alter their responses to changes in context, processes known as remapping and realignment in the hippocampus and entorhinal cortex, respectively. However, whether remapping and realignment guide context-dependent spatial behavior is unclear. To address this issue, human participants learned object-location associations within two distinct virtual reality environments and subsequently had their memory tested during functional MRI (fMRI) scanning. Entorhinal grid-like representations showed realignment between the two contexts, and coincident changes in fMRI activity patterns consistent with remapping were observed in the hippocampus. Critically, in a third ambiguous context, trial-by-trial remapping and realignment in the hippocampal-entorhinal network predicted context-dependent behavior. These results reveal the hippocampal-entorhinal mechanisms mediating human contextual memory and suggest that the hippocampal formation plays a key role in spatial behavior under uncertainty.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Comportamento Espacial
/
Mapeamento Encefálico
/
Córtex Entorrinal
/
Hipocampo
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Noruega