Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.
Nanoscale
; 13(13): 6410-6416, 2021 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-33885522
ABSTRACT
The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
SARS-CoV-2
/
Tratamento Farmacológico da COVID-19
/
Niclosamida
Limite:
Humans
Idioma:
En
Revista:
Nanoscale
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido