Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development.
J Korean Neurosurg Soc
; 64(3): 359-366, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33896149
ABSTRACT
Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells such as muscles and vertebral bones, and neural lineage cells such as neural crests and central nervous system neurons. Such diverse lineage potential combined with a limited capacity for self-renewal, which persists during axial elongation, demonstrates that NMPs are a major source of trunk tissues. This review describes the identification and characterization of NMPs across multiple species. We also discuss key cellular and molecular steps for generating neural and mesodermal cells for building up the elongating trunk tissue.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Korean Neurosurg Soc
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Austrália