New insights on mechanisms underlying methylmercury-induced and manganese-induced neurotoxicity.
Curr Opin Toxicol
; 25: 30-35, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33898886
ABSTRACT
Toxic and essential elements are widely distributed in the Earth's crust and individuals may be exposed to several of them. Indeed, exposure to toxic elements such as mercury (Hg) can be a potential health risk factor of health, mainly by ingestion of fish containing methylmercury (MeHg). On the other hand, essential elements such as manganese (Mn) play an important role in physiological process in human body. However, Mn overexposure may cause toxic effects. In this respect, the neurotoxic effects of MeHg and Mn on the developing brain are well recognized. Therefore, in this critical review, we address the effects of MeHg and Mn on cell signaling pathways which may contribute to molecular mechanisms involved in MeHg- and Mn-induced neurotoxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Curr Opin Toxicol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos