Determinants of response to hypercapnia and to progressive and transient hypoxia in obstructive sleep apnea patients.
Minerva Med
; 114(2): 178-184, 2023 Apr.
Article
em En
| MEDLINE
| ID: mdl-33913661
ABSTRACT
BACKGROUND:
The knowledge regarding the control of breathing during wakefulness in patients affected by obstructive sleep apnea (OSAS) is still challenging. The aim of this study is firstly to analyze hypoxic and hypercapnic ventilatory response in OSA patients in comparison to controls and secondly, to investigate correlations between chemosensivity and both lung function tests, such as arterial blood gas analysis and spirometric parameters, and clinical characteristics, such as age and BMI.METHODS:
Seventeen never treated OSA patients (16M; 53±13.2 years; BMI=34.5±8.1; AHI=45±14.7) underwent nocturnal cardiopulmonary monitoring test, complete lung function tests (spirometry, lung volumes and arterial blood gas analysis on room air). Read's rebreathing test was used to evaluate hypercapnic ventilatory response (HVRRESULTS:
The OSA group showed increased transient, but not progressive, HVRCONCLUSIONS:
Nocturnal intermittent hypoxic stimuli increases daytime glomic reactivity to transient hypoxia, while BMI is the main independent determinants of the bulbar response to hypercapnia in normocapnic OSAS patients.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apneia Obstrutiva do Sono
/
Hipercapnia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Minerva Med
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Itália