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Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist.
Pickford, Phil; Lucey, Maria; Rujan, Roxana-Maria; McGlone, Emma Rose; Bitsi, Stavroula; Ashford, Fiona B; Corrêa, Ivan R; Hodson, David J; Tomas, Alejandra; Deganutti, Giuseppe; Reynolds, Christopher A; Owen, Bryn M; Tan, Tricia M; Minnion, James; Jones, Ben; Bloom, Stephen R.
Afiliação
  • Pickford P; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Lucey M; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Rujan RM; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK.
  • McGlone ER; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Bitsi S; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Ashford FB; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
  • Corrêa IR; New England Biolabs, Ipswich, MA, USA.
  • Hodson DJ; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
  • Tomas A; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Deganutti G; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK.
  • Reynolds CA; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK; School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK.
  • Owen BM; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Tan TM; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Minnion J; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
  • Jones B; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK. Electronic address: ben.jones@imperial.ac.uk.
  • Bloom SR; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.
Mol Metab ; 51: 101242, 2021 09.
Article em En | MEDLINE | ID: mdl-33933675
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Receptores de Glucagon / Diabetes Mellitus Tipo 2 / Receptor do Peptídeo Semelhante ao Glucagon 1 / Hipoglicemiantes Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Mol Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Receptores de Glucagon / Diabetes Mellitus Tipo 2 / Receptor do Peptídeo Semelhante ao Glucagon 1 / Hipoglicemiantes Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Mol Metab Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido