Systemic antibiotic therapy as an adjunct to non-surgical peri-implantitis treatment: A single-blind RCT.
J Clin Periodontol
; 48(7): 996-1006, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33939193
ABSTRACT
AIM:
The aim of this single-blind RCT was to evaluate the adjunctive clinical and microbiological effect of systemic amoxicillin (AMX) plus metronidazole (MTZ) to non-surgical treatment of peri-implantitis. MATERIAL ANDMETHODS:
Patients (N = 62) with peri-implantitis were randomly assigned to receive full-mouth mechanical debridement and decontamination and use of chlorhexidine (control group) or combined with antibiotic therapy of AMX/MTZ (test group). Primary outcome was change in bleeding score from baseline (T0 ) to 3-month follow-up (T3 ). Secondary parameters were plaque, suppuration, PPD, CAL, bone level, microbiology, adverse events and need for additional surgery. Data were analysed with linear multiple regression analysis.RESULTS:
57 patients with 122 implants completed 3-month follow-up. Both groups showed major clinical improvements at T3 in both peri-implant and periodontal parameters. However, no significant differences were observed between both groups for any of the primary or secondary parameters.CONCLUSIONS:
Systemic antibiotic therapy of AMX/MTZ does not improve clinical and microbiological outcomes of non-surgical peri-implantitis treatment and should not be routinely recommended. Although complete disease resolution may be difficult to achieve, meticulously performed full-mouth non-surgical treatment, achieving a high level of daily oral hygiene and healthy periodontal tissues, can significantly improve the starting position of the subsequent (surgical) peri-implantitis treatment phase.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Implantes Dentários
/
Peri-Implantite
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
J Clin Periodontol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Holanda