Insights into the functional divergence of the haloacid dehalogenase superfamily from phosphomonoesterase to inorganic pyrophosphatase.

Yang, Ling; Lu, Yajie; Tian, Weiquan; Feng, Yulan; Bai, Jialin; Zhang, Hao

Yang, Ling; Lu, Yajie; Tian, Weiquan; Feng, Yulan; Bai, Jialin; Zhang, Hao.

Afiliação

Yang L; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, Institute of Theoretical and Simulation Chemistry, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, PR China.
Lu Y; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, Institute of Theoretical and Simulation Chemistry, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, PR China.
Tian W; Chongqing Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, Chongqing University, Huxi Campus, Chongqing 401331, PR China.
Feng Y; Biomedical Research Center, College of Life Science and Engineering, Northwest Minzu University, Lanzhou, 730030, PR China.
Bai J; Biomedical Research Center, College of Life Science and Engineering, Northwest Minzu University, Lanzhou, 730030, PR China.
Zhang H; Biomedical Research Center, College of Life Science and Engineering, Northwest Minzu University, Lanzhou, 730030, PR China. Electronic address: zhang_hao@mail.bnu.edu.cn.

Arch Biochem Biophys ; 705: 108896, 2021 07 15.

Article em En | MEDLINE | ID: mdl-33940035

Assuntos

Hidrolases/metabolismo; Pirofosfatase Inorgânica/metabolismo; Monoéster Fosfórico Hidrolases/metabolismo; Sequência de Aminoácidos; Biocatálise; Domínio Catalítico; Hidrolases/química; Cinética; Magnésio/metabolismo; Modelos Moleculares; Especificidade por Substrato

Palavras-chave

DFT; Evolution; Haloacid dehalogenase; Hydrolysis mechanism; Promiscuous catalytic activities

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monoéster Fosfórico Hidrolases / Pirofosfatase Inorgânica / Hidrolases Idioma: En Revista: Arch Biochem Biophys Ano de publicação: 2021 Tipo de documento: Article

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