Discovery of Natural Products Targeting NQO1 via an Approach Combining Network-Based Inference and Identification of Privileged Substructures.

Wu, Zengrui; Wang, Qiaohui; Yang, Hongbin; Wang, Jiye; Li, Weihua; Liu, Guixia; Yang, Yi; Zhao, Yuzheng; Tang, Yun

Wu, Zengrui; Wang, Qiaohui; Yang, Hongbin; Wang, Jiye; Li, Weihua; Liu, Guixia; Yang, Yi; Zhao, Yuzheng; Tang, Yun.

Afiliação

Wu Z; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Wang Q; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Yang H; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Wang J; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Li W; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Liu G; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Yang Y; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Zhao Y; Optogenetics & Synthetic Biology Interdisciplinary Research Center, State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing Technology, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Tang Y; CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China.

J Chem Inf Model ; 61(5): 2486-2498, 2021 05 24.

Article em En | MEDLINE | ID: mdl-33955748

Assuntos

Produtos Biológicos; Neoplasias; Produtos Biológicos/farmacologia; Descoberta de Drogas; Humanos; NAD(P)H Desidrogenase (Quinona); Neoplasias/tratamento farmacológico; Quinonas

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Chem Inf Model Assunto da revista: INFORMATICA MEDICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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