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Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
Pietrobono, Silvia; Gaudio, Eugenio; Gagliardi, Sinforosa; Zitani, Mariapaola; Carrassa, Laura; Migliorini, Francesca; Petricci, Elena; Manetti, Fabrizio; Makukhin, Nikolai; Bond, Adam G; Paradise, Brooke D; Ciulli, Alessio; Fernandez-Zapico, Martin E; Bertoni, Francesco; Stecca, Barbara.
Afiliação
  • Pietrobono S; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Florence, Italy. silvia.pietrobono@ittumori.it.
  • Gaudio E; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland.
  • Gagliardi S; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Florence, Italy.
  • Zitani M; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Florence, Italy.
  • Carrassa L; Core Research Laboratory - Institute for Cancer Research and Prevention (ISPRO), Florence, Italy.
  • Migliorini F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Petricci E; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Manetti F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
  • Makukhin N; School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, James Black Centre, Dundee, UK.
  • Bond AG; School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, James Black Centre, Dundee, UK.
  • Paradise BD; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Ciulli A; School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, James Black Centre, Dundee, UK.
  • Fernandez-Zapico ME; Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN, USA.
  • Bertoni F; Institute of Oncology Research, Faculty of Biomedical Sciences, USI, Bellinzona, Switzerland.
  • Stecca B; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.
Oncogene ; 40(22): 3799-3814, 2021 06.
Article em En | MEDLINE | ID: mdl-33958721
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Ciclo Celular / Dipeptídeos / Proteínas Hedgehog / Fatores de Transcrição SOXB1 / Proteína GLI1 em Dedos de Zinco / Guanidinas / Compostos Heterocíclicos com 3 Anéis / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Ciclo Celular / Dipeptídeos / Proteínas Hedgehog / Fatores de Transcrição SOXB1 / Proteína GLI1 em Dedos de Zinco / Guanidinas / Compostos Heterocíclicos com 3 Anéis / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália