Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives.
Bioorg Med Chem Lett
; 43: 128083, 2021 07 01.
Article
em En
| MEDLINE
| ID: mdl-33964448
ABSTRACT
A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Canais de Potássio Ativados por Cálcio de Condutância Alta
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China