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Variations between the anatomical and functional distribution, based on 99m technetium -mebrofinate SPECT-CT scan, in patients at risk of post hepatectomy liver failure.
Dasari, Bobby V M; Wilson, Michael; Pufal, Kamil; Kadam, Prashant; Hodson, James; Roberts, Keith J; Chatzizacharias, Nikolaos; Marudanayagam, Ravi; Gadvi, Rakesh; Sutcliffe, Robert P; Mirza, Darius F; Muiesan, Paolo; Isaac, John.
Afiliação
  • Dasari BVM; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom. Electronic address: bobby.dasari@yahoo.com.
  • Wilson M; Department of Nuclear Medicine, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Pufal K; University of Birmingham, B15 2TT, United Kingdom.
  • Kadam P; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Hodson J; Institute of Translational Medicine, Queen Elizabeth Hospital, Birmingham, B15 2TH, United Kingdom.
  • Roberts KJ; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Chatzizacharias N; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Marudanayagam R; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Gadvi R; Department of Nuclear Medicine, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Sutcliffe RP; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Mirza DF; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Muiesan P; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
  • Isaac J; Department of HPB and Liver Transplantation, Queen Elizabeth Hospital, Birmingham, B15 2WB, United Kingdom.
HPB (Oxford) ; 23(12): 1807-1814, 2021 12.
Article em En | MEDLINE | ID: mdl-33975803
BACKGROUND: The aim of the current study is to investigate the variations of anatomical (LVRem%) and functional remnant volumes (fLVRem%) and the dynamic uptake of Technetium-Mebrofinate (FRLF) measured from 99m Technetium-Mebrofinate SPECT-CT scan (TMSCT) in patients at high risk of post-hepatectomy liver failure (PHLF). METHODS: Variations in the measures of LVRem% and fLVRem% were assessed. The predictive accuracies of LVRem%, fLVRem% and FRLF with respect to PHLF were reported. RESULTS: From the N = 92 scans performed, LVRem% and fLVRem% returned identical results in 15% of cases, and ±10 percentage points in 79% of cases. Some patients had larger discrepancies, with difference of >10 percentage points in 21% of cases. The difference was significant in those with primary liver cancers (-4.4 ± 9.2, p = 0.002). For the N = 29 patients that underwent surgery as planned on TMSCT, FRLF was a strong predictor of PHLF, with an AUROC of 0.83 (p = 0.005). CONCLUSION: TMSCT is emerging as a useful modality in pre-operative assessment of patients undergoing major liver resection. For those with primary liver cancer, there is a significant variation in the anatomical and functional distributions that needs considered in surgical planning. Reduced FRLF, measured as the dynamic uptake in the future liver remnant, is a strong predictor of PHLF.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Falência Hepática / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: HPB (Oxford) Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Falência Hepática / Neoplasias Hepáticas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: HPB (Oxford) Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2021 Tipo de documento: Article