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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Jacobson, Peer B; Goody, Robin; Lawrence, Matthew; Mueller, Bernhard K; Zhang, Xiaomeng; Hooker, Bradley A; Pfleeger, Kimberly; Ziemann, Adam; Locke, Charles; Barraud, Quentin; Droescher, Mathias; Bernhard, Joerg; Popp, Andreas; Boeser, Preethne; Huang, Lili; Mollon, Jennifer; Mordashova, Yulia; Cui, Yi-Fang; Savaryn, John P; Grinnell, Christine; Dreher, Ingeborg; Gold, Michael; Courtine, Grégoire; Mothe, Andrea; Tator, Charles H; Guest, James D.
Afiliação
  • Jacobson PB; Department of Translational Sciences, Imaging Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America. Electronic address: peerbjacobson@gmail.com.
  • Goody R; Virscio, New Haven, CT, United States of America.
  • Lawrence M; Virscio, New Haven, CT, United States of America.
  • Mueller BK; Discovery Biology, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Zhang X; Department of Translational Sciences, Imaging Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Hooker BA; Department of Translational Sciences, Imaging Research, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Pfleeger K; Department of Neuroscience Development, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Ziemann A; Department of Neuroscience Development, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Locke C; Department of Biometrics, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Barraud Q; Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland; Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Defitech Center for Int
  • Droescher M; Discovery Biology, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Bernhard J; Discovery Biology, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Popp A; Department of Preclinical Safety, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Boeser P; Department of Preclinical Safety, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Huang L; AbbVie Biologics, AbbVie Bioresearch Center, 381 Plantation St., Worcester, MA 01605, United States of America.
  • Mollon J; Data and Statistical Sciences, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Mordashova Y; Data and Statistical Sciences, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Cui YF; Discovery Biology, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Savaryn JP; Department of Drug Metabolism and Pharmacokinetics, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Grinnell C; Department of Drug Metabolism and Pharmacokinetics, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Dreher I; Department of Bioanalytics, AbbVie Deutschland GmbH & Co. KG, Neuroscience Research, Knollstrasse, 67061 Ludwigshafen, Germany.
  • Gold M; Department of Neuroscience Development, AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States of America.
  • Courtine G; Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Geneva, Switzerland; Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; Defitech Center for Int
  • Mothe A; Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, Canada.
  • Tator CH; Division of Neurosurgery, Toronto Western Hospital, and University of Toronto, Toronto, Canada.
  • Guest JD; Department of Neurosurgery and The Miami Project to Cure Paralysis, The Miller School of Medicine, University of Miami, Miami, FL, United States of America.
Neurobiol Dis ; 155: 105385, 2021 07.
Article em En | MEDLINE | ID: mdl-33991647
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Recuperação de Função Fisiológica / Proteínas Ligadas por GPI / Neuroproteção / Anticorpos Monoclonais / Proteínas do Tecido Nervoso / Plasticidade Neuronal Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos da Medula Espinal / Recuperação de Função Fisiológica / Proteínas Ligadas por GPI / Neuroproteção / Anticorpos Monoclonais / Proteínas do Tecido Nervoso / Plasticidade Neuronal Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article