Your browser doesn't support javascript.
loading
Antiphospholipid antibodies and pregnancy outcome of assisted reproductive treatment: A systematic review and meta-analysis.
Gao, Rui; Zeng, Rujun; Qing, Pingying; Meng, Cheng; Cheng, Kemin; Zhang, Sirui; Chen, Hanxiao; Jin, Xiaolei; Qin, Lang; Li, Tao.
Afiliação
  • Gao R; The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Zeng R; Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Qing P; The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Meng C; Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Cheng K; Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China.
  • Zhang S; Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Chen H; Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Jin X; Department of Outpatients, West China Second University Hospital, Sichuan University, Chengdu, China.
  • Qin L; West China School of Medicine, Sichuan University, Chengdu, China.
  • Li T; The Reproductive Medical Center, Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Am J Reprod Immunol ; 86(4): e13470, 2021 10.
Article em En | MEDLINE | ID: mdl-34018271
PROBLEM: Antiphospholipid antibodies (aPLs) are a group of autoantibodies associated with a variety of pregnancy complications, but the impact of aPL on the outcomes of assisted fertility treatment (ART) is controversial. This systematic review and meta-analysis were designed to explore the association between aPL and ART outcomes and to explore in which stages does aPL play a role. METHOD OF STUDY: PubMed and Cochrane database were systematically retrieved, and odds ratios (ORs) or risk ratios (RRs) with 95% confidence intervals (CIs) were calculated in a random-effect model or fixed-effect model according to the heterogenicity assessed by the Cochran Q and I2  statistic test. Of 246 records identified by the search, 10 case-control studies and 13 cohort studies that explored the association between aPL and in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) were analyzed. RESULTS: The results showed that aPL positive rate was higher in females who failed in IVF/ICSI than those who succeeded in IVF/ICSI (OR: 3.62, 95% CI: 1.95-6.74). This study also indicated that females positive for aPL have a higher miscarriage rate (RR: 1.68, 95% CI: 1.24-2.28) than those negative for aPL, but live birth rate, biochemical pregnancy rate, and clinical pregnancy rate were similar between two groups (RR: 1.01, 95% CI: 0.91-1.12; RR: 1.18, 95% CI: 0.57-2.43 and RR: 0.95, 95% CI: 0.80-1.13). CONCLUSIONS: There was higher aPL prevalence in females with adverse IVF/ICSI outcomes. It seems that aPL mainly affects the miscarriage rate, but has little effect on live birth rate, biochemical pregnancy rate, and clinical pregnancy rate. Routine detection of aPL before IVF/ICSI treatment is meaningful.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Anticorpos Antifosfolipídeos / Técnicas de Reprodução Assistida Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Am J Reprod Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resultado da Gravidez / Anticorpos Antifosfolipídeos / Técnicas de Reprodução Assistida Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Am J Reprod Immunol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China