Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation.

Hawerkamp, Heike C; Domdey, Alina; Radau, Lisa; Sewerin, Philipp; Oláh, Péter; Homey, Bernhard; Meller, Stephan

Hawerkamp, Heike C; Domdey, Alina; Radau, Lisa; Sewerin, Philipp; Oláh, Péter; Homey, Bernhard; Meller, Stephan.

Afiliação

Hawerkamp HC; Department of Dermatology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Domdey A; Department of Dermatology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Radau L; Department of Dermatology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Sewerin P; Department and Hiller Research Unit for Rheumatology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
Oláh P; Department of Dermatology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Homey B; Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary.
Meller S; Department of Dermatology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

Arthritis Res Ther ; 23(1): 144, 2021 05 21.

Article em En | MEDLINE | ID: mdl-34020693

Assuntos

Antivirais; Pirimidinas; Humanos; Queratinócitos; Piperidinas; Inibidores de Proteínas Quinases; Pirróis; Linfócitos T

Palavras-chave

Antiviral immunity; Janus kinase inhibitor; Keratinocyte; T cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas Limite: Humans Idioma: En Revista: Arthritis Res Ther Assunto da revista: REUMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha

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