Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.

Lei, Yuanjiu; Guerra Martinez, Camila; Torres-Odio, Sylvia; Bell, Samantha L; Birdwell, Christine E; Bryant, Joshua D; Tong, Carl W; Watson, Robert O; West, Laura Ciaccia; West, A Phillip

Lei, Yuanjiu; Guerra Martinez, Camila; Torres-Odio, Sylvia; Bell, Samantha L; Birdwell, Christine E; Bryant, Joshua D; Tong, Carl W; Watson, Robert O; West, Laura Ciaccia; West, A Phillip.

Afiliação

Lei Y; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Guerra Martinez C; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Torres-Odio S; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Bell SL; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Birdwell CE; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Bryant JD; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Tong CW; Department of Medical Physiology, College of Medicine, Texas A&M University, Bryan, TX, USA.
Watson RO; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
West LC; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA.
West AP; Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University, Bryan, TX, USA. awest@tamu.edu.

Sci Adv ; 7(22)2021 05.

Article em En | MEDLINE | ID: mdl-34039599

Assuntos

DNA Mitocondrial; Interferon Tipo I; Envelhecimento/genética; Envelhecimento/metabolismo; Animais; DNA Mitocondrial/genética; DNA Mitocondrial/metabolismo; Inflamação/genética; Inflamação/metabolismo; Interferon Tipo I/metabolismo; Camundongos; Mitocôndrias/genética; Mitocôndrias/metabolismo; Mutação; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Interferon Tipo I Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Adv Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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