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Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies.
Rocco, Joseph M; Rosen, Lindsey B; Hong, Gloria H; Treat, Jennifer; Kreuzburg, Samantha; Holland, Steven M; Zerbe, Christa S.
Afiliação
  • Rocco JM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Rosen LB; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Hong GH; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Treat J; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Kreuzburg S; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Holland SM; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Zerbe CS; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
J Transl Autoimmun ; 4: 100102, 2021.
Article em En | MEDLINE | ID: mdl-34041472
ABSTRACT
Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production of autoantibodies. We combined bortezomib with rituximab to reduce autoantibodies leading to clinical and radiographic improvement in infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Transl Autoimmun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Transl Autoimmun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos