Radiation-Induced Senescence Reprograms Secretory and Metabolic Pathways in Colon Cancer HCT-116 Cells.

Nagineni, Chandrasekharam N; Naz, Sarwat; Choudhuri, Rajani; Chandramouli, Gadisetti V R; Krishna, Murali C; Brender, Jeffrey R; Cook, John A; Mitchell, James B

Nagineni, Chandrasekharam N; Naz, Sarwat; Choudhuri, Rajani; Chandramouli, Gadisetti V R; Krishna, Murali C; Brender, Jeffrey R; Cook, John A; Mitchell, James B.

Afiliação

Nagineni CN; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Naz S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Choudhuri R; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Chandramouli GVR; Genepria Consulting Inc., Columbia, MD 21046, USA.
Krishna MC; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Brender JR; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Cook JA; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mitchell JB; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Int J Mol Sci ; 22(9)2021 May 03.

Article em En | MEDLINE | ID: mdl-34063570

Assuntos

Senescência Celular/genética; Neoplasias do Colo/genética; Redes e Vias Metabólicas/genética; Metaboloma/genética; Senescência Celular/efeitos da radiação; Neoplasias do Colo/metabolismo; Neoplasias do Colo/patologia; Células HCT116; Humanos; Interleucina-1/genética; Interleucina-27/genética; Redes e Vias Metabólicas/efeitos da radiação; Metaboloma/efeitos da radiação; Radiação Ionizante; Fator de Crescimento Transformador beta1/genética; Fator A de Crescimento do Endotélio Vascular/genética

Palavras-chave

HCT-116; chemokines; colon cancer; cytokines; glycolysis; ionizing radiation; metabolic pathways; secretome; senescence

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular / Neoplasias do Colo / Redes e Vias Metabólicas / Metaboloma Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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