Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy.

Goel, Khushboo; Beatman, Erica L; Egersdorf, Nicholas; Scruggs, April; Cao, Danting; Berdyshev, Evgeny V; Schweitzer, Kelly S; Petrache, Irina

Goel, Khushboo; Beatman, Erica L; Egersdorf, Nicholas; Scruggs, April; Cao, Danting; Berdyshev, Evgeny V; Schweitzer, Kelly S; Petrache, Irina.

Afiliação

Goel K; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Beatman EL; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Egersdorf N; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Scruggs A; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Cao D; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Berdyshev EV; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Schweitzer KS; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.
Petrache I; Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, National Jewish Health, Denver, CO 80206, USA.

Cells ; 10(5)2021 05 14.

Article em En | MEDLINE | ID: mdl-34068927

Assuntos

Fumar Cigarros/efeitos adversos; Células Endoteliais; Pulmão; Microvasos; Receptores de Esfingosina-1-Fosfato/metabolismo; Animais; Células Cultivadas; Células Endoteliais/metabolismo; Células Endoteliais/patologia; Feminino; Humanos; Pulmão/metabolismo; Pulmão/patologia; Camundongos; Camundongos Endogâmicos C57BL; Microvasos/metabolismo; Microvasos/patologia

Palavras-chave

apoptosis; autophagy; chronic obstructive pulmonary disease; lung microvascular endothelial cells; sphingolipids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células Endoteliais / Microvasos / Fumar Cigarros / Receptores de Esfingosina-1-Fosfato / Pulmão Limite: Animals / Female / Humans Idioma: En Revista: Cells Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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