4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes.

Sun, Yu; He, Mengya; Sun, Yanling; Wei, Jianhong

Sun, Yu; He, Mengya; Sun, Yanling; Wei, Jianhong.

Afiliação

Sun Y; Department of Obstetrics, Yidu Central Hospital of Weifang, Weifang, China.
He M; Department of Obstetrics, Yidu Central Hospital of Weifang, Weifang, China.
Sun Y; Department of Obstetrics, Yidu Central Hospital of Weifang, Weifang, China.
Wei J; Department of Obstetrics, Yidu Central Hospital of Weifang, Weifang, China.

Xenobiotica ; 51(8): 871-876, 2021 Aug.

Article em En | MEDLINE | ID: mdl-34082641

Assuntos

Inibidores das Enzimas do Citocromo P-450; Microssomos Hepáticos; Citocromo P-450 CYP3A; Inibidores das Enzimas do Citocromo P-450/farmacologia; Sistema Enzimático do Citocromo P-450; Glicosídeos; Humanos; Monoterpenos

Palavras-chave

4-O-galloylalbiflorin; Paeonia lactiflora Pall; competitive inhibition; concentration-dependent inhibition; cytochrome P450 enzymes; non-competitive inhibition; time-dependent inhibition

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Inibidores das Enzimas do Citocromo P-450 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Xenobiotica Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

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