Proteopathic lesions in the brain of a super-aged chimpanzee (Pan troglodytes).

Iwaide, Susumu; Yanai, Tokuma; Murakami, Tomoaki

Iwaide, Susumu; Yanai, Tokuma; Murakami, Tomoaki.

Afiliação

Iwaide S; Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Yanai T; Hiwa Museum for Natural History, Hiroshima, Japan.
Murakami T; Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan.

J Med Primatol ; 50(4): 222-224, 2021 08.

Article em En | MEDLINE | ID: mdl-34096618

ABSTRACT

ABSTRACT

The brain of a chimpanzee estimated to be 68 years old, the oldest reported so far, has been examined. Pathological analyses revealed the formation of mild tau-positive neuritic clusters and cytoplasmic α-synuclein aggregates, in addition to severe cerebral amyloid angiopathy and diffuse plaques, but no tangle lesions were observed.

Assuntos

Doença de Alzheimer; Pan troglodytes; Peptídeos beta-Amiloides/metabolismo; Animais; Encéfalo/diagnóstico por imagem; Placa Amiloide; Proteínas tau/metabolismo

Palavras-chave

amyloid ß; brain; chimpanzee; tau; α-synuclein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pan troglodytes / Doença de Alzheimer Limite: Animals Idioma: En Revista: J Med Primatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão

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