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X-ray Structure-Guided Discovery of a Potent, Orally Bioavailable, Dual Human Indoleamine/Tryptophan 2,3-Dioxygenase (hIDO/hTDO) Inhibitor That Shows Activity in a Mouse Model of Parkinson's Disease.
Ning, Xiang-Li; Li, Yu-Zhi; Huo, Cui; Deng, Ji; Gao, Cheng; Zhu, Kai-Rong; Wang, Miao; Wu, Yu-Xiang; Yu, Jun-Lin; Ren, Ya-Li; Luo, Zong-Yuan; Li, Gen; Chen, Yang; Wang, Si-Yao; Peng, Cheng; Yang, Ling-Ling; Wang, Zhou-Yu; Wu, Yong; Qian, Shan; Li, Guo-Bo.
Afiliação
  • Ning XL; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Li YZ; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Huo C; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Deng J; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Gao C; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Zhu KR; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Wang M; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Wu YX; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Yu JL; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Ren YL; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Luo ZY; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Li G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Chen Y; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Wang SY; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Peng C; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
  • Yang LL; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Wang ZY; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Wu Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
  • Qian S; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China.
  • Li GB; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
J Med Chem ; 64(12): 8303-8332, 2021 06 24.
Article em En | MEDLINE | ID: mdl-34110158
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson Secundária / Triptofano Oxigenase / Fármacos Neuroprotetores / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase / Indazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Parkinson Secundária / Triptofano Oxigenase / Fármacos Neuroprotetores / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase / Indazóis Limite: Animals / Humans / Male Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China