Effects of Lycopene in Intestinal Ischemia Reperfusion Injury via Intestinal Immunoglobulin A.
J Surg Res
; 267: 63-70, 2021 11.
Article
em En
| MEDLINE
| ID: mdl-34130240
ABSTRACT
BACKGROUND:
Intestinal ischemia causes an inflammatory response that may become intense by reperfusion and result in bacterial translocation. Intestinal immunoglobulin A is known to be a barrier against bacterial translocation. Lycopene is a compound with antioxidant and anti-inflammatory properties. We hypothesized that lycopene has positive effects in ischemia-reperfusion of the intestine through the intestinal IgA. MATERIAL ANDMETHODS:
Twenty-eight Wistar albino rats were separated into four groups sham, control, lycopene-administered-before-ischemia (L-pre), and lycopene-administered-after-reperfusion groups. Histopathologic changes, intestinal immunoglobulin A levels, and bacterial translocation were evaluated after the ischemia-reperfusion period of 0.5-12 h.RESULTS:
Histopathologic changes, intestinal immunoglobulin A, and bacterial translocation levels in the L-pre group were similar to those in the sham group. Administration of the lycopene after reperfusion showed just a slight protective effect. However, the L-pre group had significantly fewer histopathologic changes when compared with changes in the control (P = 0.011). Intestinal immunoglobulin A level in the L-pre group was found to be higher than that in the control group (P = 0.014). Bacterial translocation levels in the blood and mesenteric lymph nodes, in the L-pre group, were lower than those in the control group (P = 0.0027 and P = 0.0097, respectively).CONCLUSIONS:
Lycopene limited intestinal damage, reduced loss of intestinal immunoglobulin A and decreased bacterial translocation when administered before the ischemia-reperfusion injury.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Traumatismo por Reperfusão
/
Licopeno
/
Intestinos
Limite:
Animals
Idioma:
En
Revista:
J Surg Res
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Turquia