The mystery of 'saturation gap' and falsely normal G6PD: a case of primaquine-induced haemolysis in Plasmodium vivax malaria infection.
J R Coll Physicians Edinb
; 51(2): 146-148, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-34131671
ABSTRACT
Eradication therapy in Plasmodium vivax in variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency individuals remains a clinical challenge. We present a case of primaquine-induced methaemoglobinaemia and haemolytic anaemia in a patient with falsely normal qualitative G6PD result during initial presentation, which was complicated with clinical sequelae of thrombosis. Further investigations showed moderate degree of G6PD deficiency. Our patient responded well to vitamin C and a modified weekly regimen of primaquine with no evidence of malaria relapse.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Vivax
/
Malária
/
Antimaláricos
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
J R Coll Physicians Edinb
Assunto da revista:
EDUCACAO
/
HISTORIA DA MEDICINA
/
MEDICINA
Ano de publicação:
2021
Tipo de documento:
Article