Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.
Ann Clin Transl Neurol
; 8(7): 1515-1523, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-34133849
ABSTRACT
Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [11 C]UCB-J PET to quantify synaptic density in comparison with 19 healthy controls and one symptomatic patient with behavioural variant frontotemporal dementia. The three pre-symptomatic C9orf72 carriers showed reduced synaptic density in the thalamus compared to controls, and there was an additional extensive synaptic loss in frontotemporal regions of the symptomatic patient. [11 C]UCB-J PET may facilitate early, pre-symptomatic assessment, monitoring of disease progression and evaluation of new preventive treatment strategies for frontotemporal dementia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Pirrolidinonas
/
Sinapses
/
Tomografia por Emissão de Pósitrons
/
Demência Frontotemporal
/
Proteína C9orf72
/
Mutação
Limite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Ann Clin Transl Neurol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Reino Unido