Your browser doesn't support javascript.
loading
Sirtuin 3 Ameliorates Lung Senescence and Improves Type II Alveolar Epithelial Cell Function by Enhancing the FoxO3a-Dependent Antioxidant Defense Mechanism.
Chen, Jian-Xin; Yang, Lei; Sun, Lu; Chen, Wei; Wu, Jie; Zhang, Chun-Feng; Liu, Kai-Yu; Bai, Long; Lu, Hong-Guang; Gao, Tong; Tian, Hai; Jiang, Shu-Lin.
Afiliação
  • Chen JX; Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Yang L; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Harbin, China.
  • Sun L; Future Medical Laboratory, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Chen W; Department of Cardiovascular Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Wu J; Future Medical Laboratory, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Zhang CF; Department of Thoracic Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Liu KY; Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Bai L; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Harbin, China.
  • Lu HG; Future Medical Laboratory, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Gao T; Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Tian H; Key Laboratory of Myocardial Ischemia, Harbin Medical University, Harbin, China.
  • Jiang SL; Future Medical Laboratory, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China.
Stem Cells Dev ; 30(17): 843-855, 2021 09 01.
Article em En | MEDLINE | ID: mdl-34148409
ABSTRACT
Lung aging alters the intrinsic structure of the lung and pulmonary surfactant system and increases the mortality and morbidity due to respiratory diseases in elderly individuals. We hypothesized that lung aging results from an insufficiency of type II alveolar epithelial cells (AECIIs) in the lung tissue. Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. Increased SIRT3 expression has been linked to an extended life span in humans. Hence, we speculated that the overexpression of SIRT3 may help to ameliorate lung senescence and improve AECII function. AECIIs were isolated from young and old patients with pneumothorax caused by pulmonary bullae. The expression of SIRT3, manganese superoxide dismutase, and catalase, as well as cell function and senescence indicators of young and old AECIIs, was measured before and after SIRT3 overexpression. After SIRT3 overexpression, the aged state of old AECIIs improved, and antiapoptotic activity, proliferation, and secretion were dramatically enhanced. Surfactant protein C (SPC), which is secreted by AECIIs, reduces alveolar surface tension, repairs the alveolar structure, and regulates inflammation. SPC deficiency in patients is associated with increased inflammation and delayed repair. SIRT3 deacetylated forkhead box O3a, thereby protecting mitochondria from oxidative stress and improving cell function and the senescent state of old AECIIs. These findings provide a possible direction for aging-delaying therapies and interventions for diseases of the respiratory system.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sirtuína 3 Limite: Aged / Humans Idioma: En Revista: Stem Cells Dev Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sirtuína 3 Limite: Aged / Humans Idioma: En Revista: Stem Cells Dev Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China