Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data.

Li, Fangyuan; Li, Jianfang; Yu, Junxian; Pan, Tao; Yu, Beiqin; Sang, Qingqing; Dai, Wentao; Hou, Junyi; Yan, Chao; Zang, Mingde; Zhu, Zhenggang; Su, Liping; Li, Yuan-Yuan; Liu, Bingya

Li, Fangyuan; Li, Jianfang; Yu, Junxian; Pan, Tao; Yu, Beiqin; Sang, Qingqing; Dai, Wentao; Hou, Junyi; Yan, Chao; Zang, Mingde; Zhu, Zhenggang; Su, Liping; Li, Yuan-Yuan; Liu, Bingya.

Afiliação

Li F; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Li J; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Yu J; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Pan T; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Yu B; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Sang Q; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Dai W; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China; Shanghai Center for Bioinformation Technology, Shanghai Engineering Research Center of Pharmaceu
Hou J; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Yan C; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Zang M; Department of Gastric Cancer Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, 200032 Shanghai, PR China.
Zhu Z; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Su L; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China.
Li YY; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China; Shanghai Center for Bioinformation Technology, Shanghai Engineering Research Center of Pharmaceu
Liu B; Department of Surgery, Shanghai Key Laboratory of Gastric Neoplasms, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, PR China. Electronic address: liubingya@sjtu.edu.cn.

EBioMedicine ; 69: 103436, 2021 Jul.

Article em En | MEDLINE | ID: mdl-34157484

Assuntos

Biomarcadores Tumorais/genética; Peptídeos e Proteínas de Sinalização Intracelular/genética; Neoplasias Gástricas/genética; Transcriptoma; Adenosina Trifosfatases/genética; Adenosina Trifosfatases/metabolismo; Animais; Biomarcadores Tumorais/metabolismo; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular Tumoral; Proliferação de Células; Células Cultivadas; RNA Helicases DEAD-box/genética; RNA Helicases DEAD-box/metabolismo; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Regulação Neoplásica da Expressão Gênica; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Proteínas de Neoplasias/genética; Proteínas de Neoplasias/metabolismo; Organoides/crescimento & desenvolvimento; Organoides/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo; Neoplasias Gástricas/metabolismo; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo; Regulação para Cima

Palavras-chave

ARGLU1; Gastric cancer; Prognostic model; Therapeutic target

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Biomarcadores Tumorais / Peptídeos e Proteínas de Sinalização Intracelular / Transcriptoma Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans / Male Idioma: En Revista: EBioMedicine Ano de publicação: 2021 Tipo de documento: Article

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