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Bilateral testicular germ cell tumors - 50 years experience.
Bratisl Lek Listy ; 122(7): 449-453, 2021.
Article em En | MEDLINE | ID: mdl-34161111
ABSTRACT

OBJECTIVE:

This study analysed the characteristics and outcome of the patients with bilateral germ testicular cell cancer (TC), especially synchronous.

METHODS:

Among 2.124 TC patients diagnosed between 1970 and 2020, 96 (4. 5%) developed the 2nd TC. Nine occurred synchronously and 87 were metachronous. Patients were analysed according to the age and histological type of bilateral TC in comparison with unilateral TC.

RESULTS:

The mean follow-up of all 2,124 patients was 14.9 years. Unilateral TC occurred in 2.028 patients (the mean age of 32.4 years), 707 of them had seminoma, 1.310 nonseminomatous (NS) TC and 11 spermatocytic tumours. The 1st tumour of metachronous bilateral disease was diagnosed at a significantly younger age (27.1 years) compared to the unilateral disease (32.4 years). The mean interval between the 1st and the 2nd TC was 8.2 years. Patients with NSTC had a longer mean interval (9.2 years) between the 1st and the 2nd TC in comparison with seminoma patients (6.7 years). The mean age at diagnosis for seminoma was significantly higher (31.3 years) compared to the NSTC (24.1 years). Bilateral seminoma occurred in 5 synchronous bilateral TC patients, four patients had discordant histology, none presented with bilateral NSTC.

CONCLUSIONS:

Bilateral TC is a rare and requires individualized management of patients (Tab. 5, Fig. 4, Ref. 32).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Segunda Neoplasia Primária / Seminoma / Neoplasias Embrionárias de Células Germinativas Limite: Adult / Humans / Male Idioma: En Revista: Bratisl Lek Listy Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Testiculares / Segunda Neoplasia Primária / Seminoma / Neoplasias Embrionárias de Células Germinativas Limite: Adult / Humans / Male Idioma: En Revista: Bratisl Lek Listy Ano de publicação: 2021 Tipo de documento: Article